Lipidomics of radical stress

Free radicals react with unsaturated lipids and induce chemical transformations, which can have a double role, as signal or damage, determining different cellular responses. The lipid double bonds and the conservation of the cis geometry have a crucial significance for cell membrane properties. Together with the peroxidation processes, this reactivity makes part of the lipid remodeling occurring under cellular stress. Our research aims at providing a complete scenario of free radical lipid transformations, envisaging membranes as an important compartment for adaptation and metabolic recovery, through rapid reorganization and turnover. Part of this research has an important and straightforward application to biomarker discovery and to developments for health and nutra-companies.

The following research aspects are developed:

• Chemical basis and reactivity of free radicals with biological membranes

• Lipid remodeling in vitro and in vivo under stress

• Trans fatty acids in life sciences

• The role of biologically relevant small radicals in the cis—trans isomerization

• Endogenous protection of the cis lipid geometry: the role of enzymatic and molecular defenses

• Molecular libraries for recognitions of trans lipids

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