Chemical Sciences for Nanostructures and Biological Applications

The program comprises 11 researchers performing multidisciplinary research at the molecular, macromolecular and mesoscopic scales targeting applications in health, technology and the environment.

Current topics include:

  • Total synthesis of natural products; design, synthesis and chemical biology of related analogues for applications in life sciences.
  • Design and synthesis of small organic molecules for applications in microlithography and organic electronics.
  • Development of cyclodextrin-based multimodal molecular/drug transporters and release systems.
  • Development of new biomarkers related to DNA damage, repair mechanisms and lipid transformations.
  • Synthesis, characterization and biological evaluation of organic and inorganic polymeric nanocontainers as drug delivery systems for targeted therapy.
  • Macromolecular crystallization methods and crystal structure analysis of biomacromolecules.
  • Development of new or modified nanomaterials based on electron and nuclear spins (e.g. trapped atoms in silicon-oxide) with long spin coherence times for quantum computing applications.
  • Supramolecular synthesis, via self-assembly, of artificial biomimetic light-harvesting functional materials for performing specific light functions e.g., accumulation and tuning in fluorescence, up-conversion of light, electronic energy transfer (EET), EET based sensing systems, molecular machinery, solar energy conversion etc.
  • Structural studies and characterization of molecular/supramolecular entities, macromolecules and related nanostructures by high resolution liquid state NMR, pulsed EPR, ENDOR, Raman, UV-Vis, fluorescence emission and FT-IR spectrometers, DLS, as well as AFM, STM and X-ray crystallography.
  • Theoretical studies and computational modeling of complex dynamical systems, including nonlinear dynamics, neuron networks (based on MRI, f-MRI and EEG data), bioinformatics and kinetic Monte Carlo methods for stochastic processes.
  • Computational studies using semiempirical, density functional and ab-initio methods for the prediction of structural and thermochemical properties of molecular systems with pharmaceutical and environmental interest.
  • Numerical study of the magnetic properties and the dynamic behavior of nanostructured materials for energy, environmental and biomedical applications, using multi-scale modeling. The numerical techniques include: ab-initio calculations, Molecular Dynamics and Monte Carlo simulations.

The program addresses the path from research to innovation in all these strategic topics with a strong commitment to national, European and international competitiveness.