Funded Projects

Title: Nanoparticle mediated Photochemical Internalisation (PCI) of small anticancer drugs
Acronym: PCInano
Leader: Konstantina Yannakopoulou
Start Date: 1/6/2016
End Date: 14/01/2021
Category: ERA-NET, Euronanomed II


Current chemotherapy has drawbacks such as side effects and drug resistance. The PCInano project implements novel nanoparticle-based, cancer specific drug delivery systems, enabling controlled chemotherapy release upon light irradiation. This is implemented by parallel administration of the PCInano nanocarriers with a light-activatable agent (photosensitiser, PSs). The role of the NCSRD partner is to prepare cyclodextrin-based nanoparticles that carry drugs encapsulated in their cavity and are simultaneously conjugated with designed PSs. The resulting assemblies are used as delivery systems combining chemotoxicity, phototoxicity and fluorescence imaging capability.