Research Interests : cyclodextrin chemistry; supramolecular chemistry; NMR spectroscopic studies of molecules and host-guest systems; cyclodextrin-based bioactive and photoactive nanoconstructs

Email : k.yannakopoulou@inn.demokritos.gr

Research Interests
cyclodextrin chemistry; supramolecular chemistry; NMR spectroscopic studies of molecules and host-guest systems; cyclodextrin-based bioactive and photoactive nanoconstructs
Position
Researchers
Telephone
+ 30 210 650 3796
About/Biography
BS in Chemistry, University of Athens; MSc in Chemsitry, Clemson University, USA (Prof. R.A. Abramovitch); PhD in Chemistry, University of Florida, USA (1988, Prof. A. R. Katritzky). Post-doctoral fellow: University of Florida, USA, 1988-1989; NCSR “Demokritos” (1989-1993). Currently Researcher A at the Institute of Nanoscience and Nanotechnology, NCSR “Demokritos”. Research interests: molecular structure-properties relations and particularly characterization of host/guest interactions, stability and equilibria of cyclodextrin-guest systems, synthetic modifications of cyclodextrins to functional host molecules and their bio and nano applications (nucleotide and DNA carriers, cell penetrating agents and also as antimicrobial agents). The research focus has also been expanded to photoactive molecules and their nanoconstructs with cyclodextrins as multifunctional bio and photo active hosts systems combining ROS production, drug transport and photoimaging for chemotoxic and photodynamic applications. Supervised five MSc and eleven PhD students, one in progress. Coordinator of the EU FP7 project PEOPLE-ITN “Novel multifunctional cyclodextrin- based nanocarriers for drug encapsulation and delivery as a strategy to overcome current therapeutic drawbacks”, CYCLON (2009-2013). Partner in the FP7-ITN “Nanocarriers for the delivery of antimicrobial agents to fight resistance mechanisms” CycloN-Hit (2014-2018). Partner in ERA-NET EuroNanomed-II-JTC2015 "Nanoparticle mediated Photochemical internalization (PCI) of small anticancer drugs" PCInano project (2016-2019).
Scientist in Charge of the high resolution NMR Lab for liquid samples for NCSR “Demokritos” since 1991. Authored and co-authored 95 articles in international refereed journals, one book chapter, and participated in 80 national and international conferences.
Updated Jan 2019.

Representative Publications:

“Positively charged cyclodextrins as effective molecular transporters of active phosphorylated forms of gemcitabine into cancer cells”,
V. Rodriguez-Ruiz, A. Maksimenko, G. Salzano, M. Lampropoulou, Y. G. Lazarou, V. Agostoni, R. Gref, K. Yannakopoulou
Scientific Reports 2017, 7: 8353.

“Designed positively charged cyclodextrin hosts with enhanced binding of penicillins as carriers for the delivery of antibiotics: the case of oxacillin”, M. Agnes, A. Thanassoulas, P. Stavropoulos, G. Nounesis, G. Miliotis, V. Miriagou, E. Athanasiou, G. Benkovics, M. Malanga, K. Yannako¬poulou
Int. J. Pharm. 2017, 531, 480-491.

"Anionic cyclodextrins as versatile hosts for pharmaceutical nanotechnology: Synthesis, drug delivery, enantioselectivity, contrast agents for MRI (Review)”
I. M. Mavridis, K. Yannakopoulou
Int. J. Pharm. 2015, 492 (1-2), 275-290.

“Photochemical Internalization of Tamoxifens Transported by a “Trojan-Horse” Nano¬conjugate into Breast-Cancer Cell Lines”
T. A. Theodossiou, A. R. Goncalves, K. Yannakopoulou, E. Skarpen, K. Berg
Angew. Chem. Int. Ed. 2015, 54(16), 2015, 4885–4889.

“A Multifunctional Bichromophoric Nanoaggregate for Fluorescence Imaging and Simultaneous Photogeneration of RNOS and ROS”
A. Fraix, A. R. Gonçalves, V. Cardile, A. C. E. Graziano, T. A. Theodossiou, K. Yannakopoulou, S. Sortino
Chem. Asian J. 2013, 8(11), 2634-2641.

“Symmetry requirements for the effective blocking of pore-forming toxins: Comparative study with α-, β-, and γ-cyclodextrin derivatives”
K. Yannakopoulou, L. Jicsinszky, C. Aggelidou, N. Mourtzis, T. M. Robinson, A. Yohannes, E. M. Nestorovich, S. Bezrukov, V. A. Karginov
Antimicrob. Agents Chemother. (AAC), 2011, 55, 3594-3597.