PSA and TSA are commonly used methods to separate gas mixtures with the aid of sorbent materials. The present invention regards a modified such method, in which instead of swinging pressure or temperature, a magnetic field in the region of a paramagnetic liquid absorbent is repeatedly switched ON/OFF. It relies on the observation that the magnetic field enhances kinetic of gas absorption into the liquid, caused either by a change in liquid/gas interface (area or chemistry change), or by field-induced agitation. Consequently, by switching the magnetic field ON and OFF a different transient curve of absorbed amount vs. time is followed and an amount of gas is absorbed and desorbed, respectively, without externally changing pressure or temperature. Since the magnetic enhancement is different for different gases of a gas mixture, field pulsing results in selective swing sorption.

 A gravimetric microbalance is commonly used to measure adsorbed gas amount on sorbent materials. The present invention regards a modified gravimetric microbalance, in which the hanging sample holder is located in a space where a magnetic field can be turned on and off. This modification provides the additional capability to measure the ratio of adsorbed amounts of two gases, being simultaneously adsorbed to the same sample. Consequently, real adsorption selectivity can be calculated.

The existence of magnetic field around the carbon molecular sieve hollow fiber membranes’ module provide a slight increase of gas separation performance in gases such as H₂/CH₄. This evidence together with the design of the described apparatus is presented and discussed in this invention.

A new sensor for online monitoring of the structural stability of concrete constructions has been developed from nanocomposite cement materials. The change on the electrical resistance, as a function of the mechanical strengthens; of the nanocomposite material, is the main tool which is taking into advance for this application.

In one aspect, the present disclosure provides shishijimicin analogs. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, antibody drug conjugates of the compounds are also provided.

An integrated microdevice for amplification and detection of nucleic acids comprises a microreactor for nucleic acid amplification in the form of a microfluidic amplification microchamber or in the form of a microchannel, fabricated in one layer of a multilayer PCB structure, a detection microchamber for electrochemical biosensing with a sensing noble-metal plated electrode array allowing the effective immobilization of nucleic acid target probes and electronic quantification of the previously amplified target sequences fabricated in the same PCB layer as the said microreactor, a microchannel network for delivering the amplified nucleic acid to the said sensing electrode array, fabricated in the same PCB layer as the said microreactor, and resistive microheaters for providing the heating zones for nucleic acid amplification and/or denaturation, fabricated in a PCB layer under the microreactor and/or the said sensing electrode array.

 The present invention proposes a way for coupling light in and out of an integrated interferometer or resonator through the use of photonic chips with one-sided optical ports and the employment of bifurcated fibers. The bifurcated fiber at the common end matches the input and output waveguide pair at the one-sided optical port of the planar photonic chip.

Synthesis of Tubulysin analogues, their use in antibody-drug conjugates and their evaluation in anticancer therapy.

Synthesis of structurally modified Imatinib analogues and their evaluation as tyrosine kinase inhibitors for anticancer therapy.

Synthesis and biological evaluation of novel aminopeptidase inhibitors in anticancer therapy.

The patent is on the methodology of synthesis of a nano-silica oxalate gel with the capacity to be used for consolidation and surface protection of modern, traditional and archaeological porous structure materials such as stone, mortars, which has been deteriorated due to biological or environmental parameters.

The patent gives the method to synthesize the compound Ciprofloxacin-Silver with antibacterial properties against Pseudomonas aeruginosa which is the most often occurring negative bacterium of cornea.

Hybrid nanospheres containing metal nanoparticles biomimetically reduced into the cavities of hyperbranched poly(ethylene imine) are described. The latter acts as matrix for a subsequent second biomimetic production of a silica shell. These composite materials were successfully applied as catalysts and antibacterial agents.

This invention describes the development of innovative drug delivery systems based on functional  dendritic polymers bearing on their surface appropriate groups that make them effective in targeting cell mitochondria, and in particular mitochondria of cancer cells. These systems are able to encapsulate aminoquinolines and their derivatives enhancing their therapeutic effect against various cancer cells.

The current invention presents the development of innovative nanocomposite materials based on functionalized dendritic polymers with symmetrical or asymmetrical architecture or based on functionalized inorganic nanoparticles (metal or metal oxide nanoparticles or mixed metal oxide nanoparticles). Both the polymeric nanoparticles and the inorganic nanoparticles are functionalized with appropriate lipophilic groups. These nanocomposite materials that describe the current invention, exhibit micro slime layer control properties and can be effectively applied to objects submerged in sea water as fouling release coatings.

The invention presents the development of novel nanocomposites using polymeric nanoparticles based on dendrimers. The final coatings present fouling release properties preventing the formation of the micro-slime layer.

The present invention deals with the development of functionalized nanostructured carbon-based materials with antibacterial properties as well as their effect on the photosynthetic process. Additionally, these hybrid materials can be incorporated or coated to any material or substrate (polymers, metal, wood, woven and nonwoven textile materials, plastics, thermoplastics, synthetic or composite materials, etc.) affording surfaces with antibacterial properties. Furthermore, an in situ, direct and instrumental method for the evaluation and assessment of antibacterial properties of types of materials or surfaces is described.

The invention deals with the development of functionalized nanostructured carbon-based materials with antibacterial properties as well as their effect on the photosynthetic process. Additionally, these hybrid materials can be incorporated or coated to any material or substrate (polymers, metal, wood, woven and nonwoven textile materials, plastics, thermoplastics, synthetic or composite materials, etc.) affording surfaces with antibacterial properties

 Development of a bubble generator for producing bubbles of controlled size such as microbubbles, nanobubbles and ultra-nanobubbles accompanied by a methodology of their management in the bulk of a solution.

All these patents describe inventions related to wireless charging technologies, a revolutionary effort at creating viable technologies transferring meaningful Radio Frequency (RF) power to mobile devices.

The patent application describes microfluidic reactors comprising at least one channel and/or at least one chamber on printed circuit boards or on a flexible printed circuit sheet, which are sealed by a polyimide sealing film with an acrylic adhesive, and process for the manufacture of such reactors and their uses.

A new plasma etching apparatus with simultaneous co-sputtering of controlled amount of electrode material is proposed for the production of controlled nanotexturing on a polymeric surface.

A new plasma nanotextured microfluidic device with high surface area and COOH group density is proposed for DNA purification.

 A new atmospheric pressure processing apparatus is proposed on a printed circuit board electrode for uniform area plasma production.

Plasma nanotextured and thermally annealed substrates are ideal for covalent-like binding of biomolecules and due to the increased surface area lead to 100x increased sensitivity of detection.

Plasma nanotextured polymeric substrates are used as surfaces to grow mixtures of cells (e.g. from blood or biopsy). It is observed that cancerous cells adhere more and are enriched on the surface.

An optical biosensing set up is described based on integrated broad-band Young interferometer and capable of projecting on the imaging array two distinct packets of interference fringes, one for TE and the other for TM polarization. With an adlayer growing on the sensing arm, the packet shifts faster than the on chip phase difference between the two arms providing an amplified optical signal over a range of wavelengths. The set up incorporates broad-band light sources, external or integrated, the photonic chip with the Young interferometer, and an imaging array. The imaging array can be on-chip integrated or external. The fringe shifts monitored at the imaging array present a measure of the biomolecular adlayer built-up.

A photonic chip based optical set-up is outlined for detecting analyte molecules through integrated optical interferometry and/or resonance. The set-up incorporates light sources, bifurcated fibers, photonic chips with one-sided optical ports and integrated interferometers/or resonators, a mechanical optical coupling module, and detector units. The photonic chip is directly interfaced with the bifurcated fiber so light enters the chip through the input fiber/input waveguide interface and light exits the chip from the same side through the output waveguide/output fiber interface. No reflection based interferometry is employed. The spectral shifts monitored at the detector unit provide a measure of the molecular adlayer built-up.