Converging Lamb wave sensors with micro-technologies towards an integrated Lab-on-Chip for clinical analysis
The project LAMBSENSE is based on the development of a fully integrated platform for diagnostic purposes incorporating an array of acoustic wave biochips as the sensing element, a microfluidic module for the parallel detection of several analytes and a heater-integrated micro-PCR (developed by our group) for in situ DNA amplification. The devices, based on a novel Lamb wave acoustic geometry, will use a gallium nitride thin membrane film for supporting the acoustic wave and will operate at a frequency range of 100-300 MHz (developed by the Biosensors group, FORTH & Univ. Crete). Acoustic measurements are carried out thanks to a compact read-out system, designed to provide high accuracy as well as simple and inexpensive instrumentation. The potential of this platform towards clinical applications is further exploited during the detection of genetic biomarkers for bacteria in biological samples. The final goal of this work is to offer a robust, inexpensive and competitive detection platform that could manage the problem of the rapid identification of resistant pathogens in a clinical or point-of-care setting.