Irene M. Mavridis obtained the Degree of Chemistry from the National and Kapodistrian University of Athens. After a short stay in NRC “Demokritos”, as a post-graduate student (with Dr C. Zioudrou on asymmetric synthesis), she enrolled in the graduate program of Michigan State University USA, where she earned a PhD in Physical Chemistry (1975, Prof. Alexander Tulinsky). Thesis title “Structure Determination of 2-keto-3-deoxy-6-Phosphogluconate Aldolase (Pseudomonas Putida) at 3.5A Resolution”. In 1976, she joined the Institute of Physical Chemistry of NCSR “Demokritos” (NCSRD). During the years 1976, 1978, 1979-1980 and 1987 she has been a visiting researcher at Michigan State University for time periods of 3-12 months. She directed the Laboratory of Structural and Supramolecular Chemistry from 1995 till her retirement in 2011. Research interests: molecular structure determination by X-ray crystallography; organization and structure-function relations of cyclodextrins and their inclusion complexes, as well as photochromism/thermochromism of Schiff bases; structural determination of biological macromolecules.

I. M. Mavridis was in charge of the Laboratory of Macromolecular Crystallography in NCSRD since its establishment in 1998 and Chair of the Hellenic Crystallographic Association for several terms. She has co-organized several international conferences, workshops and schools and has served in numerous scientific committees in Greece and in other European countries. Moreover, she has served as a PI or collaborator in numerous research projects and networks.

I. M. Mavridis  has authored and co-authored 116 articles in international refereed journals (of which 6 are book chapters), five patents and has presented her research in more than 120 international conferences. Number of citations, 4375 (Google Scholar).


  1. S. Makedonopoulou, I. M. Mavridis, K. Yannakopoulou, J. Papaioannou, Organization of Long Aliphatic Monocarboxylic Acids in β-Cyclodextrin Channels. Crystal Structures of the Inclusion Complexes of Tridecanoic Acid and (Z)-tetradecenoic Acid in β-Cyclodextrin, J. Chem. Soc. Chem. Commun., 1998, 2133-2134.
  2. Ε. Hadjoudis, I. M. Mavridis, Photochromism and Thermochromism of Schiff Bases in the Solid State: Structural Aspects, Chem. Soc. Rev., 2004, 33, 579- 588.
  3. P. Zou, N. Pinotsis, S. Lange, Y-H. Song, A. Popov, I. Mavridis, O. M. Mayans, M. Gautel, M. Wilmanns, Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk, Nature, 2006 439, 225-228.
  4. E. Saridakis, P. Giastas, G. Efthymiou,2 V. Thoma, J-M. Moulis, P. Kyritsis, I. M. Mavridis, Insight into the protein and solvent contributions to the reduction potentials of [4Fe-4S]2+/+ clusters: Crystal structures of the Allochromatium vinosum ferredoxin variants C57A and V13G and the homologous Escherichia coli ferredoxin, J. Biolog. Inorg. Chem. 2009, 14, 783-799.
  5. J. R. Birtley, E. Saridakis, E. Stratikos, I. M. Mavridis, Crystal Structure of Human ER Aminopeptidase 2 Reveals Atomic Basis for Distinct Roles in Antigen Processing, Biochemistry, 2012, 51, 286–295.
  6. I. M. Mavridis,  K. Yannakopoulou, Porphyrinoid-Cyclodexrin Assemblies in Biomedical Research: an Update. J. Med. Chem. 2020, 63, 7, 3391-3424. https://doi.org/10.1021/acs.jmedchem.9b01069
  7. A self-locked β-cyclodextrin-rhodamine B spirolactam with photoswitching properties. S. Panagiotakis, E. Saridakis, M. Malanga, I. M. Mavridis, K. Yannakopoulou., Chem. Asian J. 2021 (on-line: 25-11). https://doi.org/10.1002/asia.202101282


Agnes, M., Kasimati, E.M., Inclán, M., Thanassoulas, A., Miliotis, G., Malanga, M., Benkovics, G., Nounesis, G., García-España, E., Bouziotis, P., Lazarou, Y.G., Miriagou, V., Mavridis, I.M. and Yannakopoulou, K., Metal-binding cyclodextrins: Synthesis and complexation with Zn2+ and Ga3+ cations towards antimicrobial applications Carbohydrate Polymers, Volume 321, Article Number: 121323, 2023 [doi]

Saridakis, E., Kasimati, E.-M., Yannakopoulou, K. and Mavridis, I.M., A guanidino-γ-cyclodextrin superdimer generates a twin receptor for phosphate dimers assembled by anti-electrostatic hydrogen bonds Chemical Communications, Volume 58, Pages: 5300-5303, 2022 [doi]

Panagiotakis, S., Saridakis, E., Malanga, M., Mavridis, I.M. and Yannakopoulou, K., A Self-locked β-Cyclodextrin-rhodamine B Spirolactam with Photoswitching Properties Chemistry - An Asian Journal, Volume 17, Article Number: e202101282, 2022 [doi]

Mavridis, Irene M and Yannakopoulou, Konstantina, Porphyrinoid–Cyclodextrin assemblies in biomedical research: an update Journal of medicinal chemistry, American Chemical Society, Volume 63, Pages: 3391–3424, 2019 [doi]

Pistolis, George, Petrakis, Vyron S, Kournoutas, Fotis, Karakostas, Nikolaos, Martinou, Elisabeth, Efthimiadou, Eleni K, Fakis, Mihalis and Mavridis, Irene M, Cooperative Self-Assembly Enables Two-Dimensional H-type Aggregation of a Sterically Crowded Perylene-Bisimide Dimer Crystal Growth & Design, ACS Publications, Volume 19, Pages: 4252–4263, 2019 [doi]

Chatziefthimiou, S.D., Inclán, M., Giastas, P., Papakyriakou, A., Yannakopoulou, K. and Mavridis, I.M., Molecular recognition of N-acetyltryptophan enantiomers by β-cyclodextrin Beilstein Journal of Organic Chemistry, Volume 13, Pages: 1572-1582, 2017 [doi]

Mpakali, A., Giastas, P., Deprez-Poulain, R., Papakyriakou, A., Koumantou, D., Gealageas, R., Tsoukalidou, S., Vourloumis, D., Mavridis, I.M., Stratikos, E. and Saridakis, E., Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency ACS Medicinal Chemistry Letters, Volume 8, Pages: 333-337, 2017 [doi]

Lampropoulou, M., Misiakos, K., Paravatou, M., Mavridis, I.M. and Yannakopoulou, K., Synthesis of cyclodextrin derivatives with monosacharides and their binding with ampicillin and selected lectins Arkivoc, Volume 2015, Pages: 232-243, 2015 [doi]

Mpakali, Anastasia, Giastas, Petros, Mathioudakis, Nikolas, Mavridis, Irene M, Saridakis, Emmanuel and Stratikos, Efstratios, Structural basis for antigenic peptide recognition and processing by endoplasmic reticulum (ER) aminopeptidase 2 Journal of Biological Chemistry, Elsevier, Volume 290, Pages: 26021–26032, 2015 [doi]

Mavridis, Irene M. and Yannakopoulou, Konstantina, Anionic cyclodextrins as versatile hosts for pharmaceutical nanotechnology: Synthesis, drug delivery, enantioselectivity, contrast agents for MRI INTERNATIONAL JOURNAL OF PHARMACEUTICS, Volume 492, Pages: 275-290, 2015 [doi]

Manouilidou, M.D., Lazarou, Y.G., Mavridis, I.M. and Yannakopoulou, K., Staudinger ligation towards cyclodextrin dimers in aqueous/organic media. Synthesis, conformations and guest-encapsulation ability Beilstein Journal of Organic Chemistry, Volume 10, Pages: 774-783, 2014 [doi]

Karakostas, Nikolaos, Mavridis, Irene M, Seintis, Kostas, Fakis, Mihalis, Koini, Eftychia N, Petsalakis, Ioannis D and Pistolis, George, Highly efficient and unidirectional energy transfer within a tightly self-assembled host–guest multichromophoric array Chemical Communications, Royal Society of Chemistry, Volume 50, Pages: 1362–1365, 2014 [doi]

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