Irene M. Mavridis obtained the Degree of Chemistry from the National and Kapodistrian University of Athens. After a short stay in NRC “Demokritos”, as a post-graduate student (with Dr C. Zioudrou on asymmetric synthesis), she enrolled in the graduate program of Michigan State University USA, where she earned a PhD in Physical Chemistry (1975, Prof. Alexander Tulinsky). Thesis title “Structure Determination of 2-keto-3-deoxy-6-Phosphogluconate Aldolase (Pseudomonas Putida) at 3.5A Resolution”. In 1976, she joined the Institute of Physical Chemistry of NCSR “Demokritos” (NCSRD). During the years 1976, 1978, 1979-1980 and 1987 she has been a visiting researcher at Michigan State University for time periods of 3-12 months. She directed the Laboratory of Structural and Supramolecular Chemistry from 1995 till her retirement in 2011. Research interests: molecular structure determination by X-ray crystallography; organization and structure-function relations of cyclodextrins and their inclusion complexes, as well as photochromism/thermochromism of Schiff bases; structural determination of biological macromolecules.

I. M. Mavridis was in charge of the Laboratory of Macromolecular Crystallography in NCSRD since its establishment in 1998 and Chair of the Hellenic Crystallographic Association for several terms. She has co-organized several international conferences, workshops and schools and has served in numerous scientific committees in Greece and in other European countries. Moreover, she has served as a PI or collaborator in numerous research projects and networks.

I. M. Mavridis  has authored and co-authored 116 articles in international refereed journals (of which 6 are book chapters), five patents and has presented her research in more than 120 international conferences. Number of citations, 4375 (Google Scholar).


  1. S. Makedonopoulou, I. M. Mavridis, K. Yannakopoulou, J. Papaioannou, Organization of Long Aliphatic Monocarboxylic Acids in β-Cyclodextrin Channels. Crystal Structures of the Inclusion Complexes of Tridecanoic Acid and (Z)-tetradecenoic Acid in β-Cyclodextrin, J. Chem. Soc. Chem. Commun., 1998, 2133-2134.
  2. Ε. Hadjoudis, I. M. Mavridis, Photochromism and Thermochromism of Schiff Bases in the Solid State: Structural Aspects, Chem. Soc. Rev., 2004, 33, 579- 588.
  3. P. Zou, N. Pinotsis, S. Lange, Y-H. Song, A. Popov, I. Mavridis, O. M. Mayans, M. Gautel, M. Wilmanns, Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk, Nature, 2006 439, 225-228.
  4. E. Saridakis, P. Giastas, G. Efthymiou,2 V. Thoma, J-M. Moulis, P. Kyritsis, I. M. Mavridis, Insight into the protein and solvent contributions to the reduction potentials of [4Fe-4S]2+/+ clusters: Crystal structures of the Allochromatium vinosum ferredoxin variants C57A and V13G and the homologous Escherichia coli ferredoxin, J. Biolog. Inorg. Chem. 2009, 14, 783-799.
  5. J. R. Birtley, E. Saridakis, E. Stratikos, I. M. Mavridis, Crystal Structure of Human ER Aminopeptidase 2 Reveals Atomic Basis for Distinct Roles in Antigen Processing, Biochemistry, 2012, 51, 286–295.
  6. I. M. Mavridis,  K. Yannakopoulou, Porphyrinoid-Cyclodexrin Assemblies in Biomedical Research: an Update. J. Med. Chem. 2020, 63, 7, 3391-3424. https://doi.org/10.1021/acs.jmedchem.9b01069
  7. A self-locked β-cyclodextrin-rhodamine B spirolactam with photoswitching properties. S. Panagiotakis, E. Saridakis, M. Malanga, I. M. Mavridis, K. Yannakopoulou., Chem. Asian J. 2021 (on-line: 25-11). https://doi.org/10.1002/asia.202101282


Panagiotakis, Stylianos, Mavroidi, Barbara, Athanasopoulos, Alexandros, Charalambidis, Georgios, Coutsolelos, Athanassios G, Paravatou-Petsotas, Maria, Pelecanou, Maria, Mavridis, Irene M and Yannakopoulou, Konstantina, Unsymmetrical, monocarboxyalkyl meso-arylporphyrins in the photokilling of breast cancer cells using permethyl-$beta$-cyclodextrin as sequestrant and cell uptake modulator Carbohydrate Polymers, Elsevier, Volume 275, Pages: 118666, 2022 [doi]

Mavridis, Irene M and Yannakopoulou, Konstantina, Porphyrinoid–Cyclodextrin assemblies in biomedical research: an update Journal of medicinal chemistry, American Chemical Society, Volume 63, Pages: 3391–3424, 2019 [doi]

Chatziefthimiou, Spyros D., Inclan, Mario, Giastas, Petros and Papakyriakou, Athanasios, Yannakopoulou, Konstantina and Mavridis, Irene M., Molecular recognition of N-acetyltryptophan enantiomers by beta-cyclodextrin BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, Volume 13, Pages: 1572-1582, 2017 [doi]

Mavridis, Irene M. and Yannakopoulou, Konstantina, Anionic cyclodextrins as versatile hosts for pharmaceutical nanotechnology: Synthesis, drug delivery, enantioselectivity, contrast agents for MRI INTERNATIONAL JOURNAL OF PHARMACEUTICS, Volume 492, Pages: 275-290, 2015 [doi]

Manouilidou, M.D., Lazarou, Y.G., Mavridis, I.M. and Yannakopoulou, K., Staudinger ligation towards cyclodextrin dimers in aqueous/organic media. Synthesis, conformations and guest-encapsulation ability Beilstein Journal of Organic Chemistry, Volume 10, Pages: 774-783, 2014 [doi]

Hadjoudis, Eugene, Yannakopoulou, Konstantina, Chatziefthimiou, Spyros D., Paulidou, Anastasia and Mavridis, Irene M., Supramolecular control of photochromism in a beta-cyclodextrin/Schiff base system JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, Volume 217, Pages: 293-298, 2011 [doi]

Mavridis, Irene M., Chatziefthimiou, Spyros D. and Yannakopoulou, Konstantina, Molecular imprinting effect of the guest in beta-cyclodextrin inclusion complexes ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, Volume 67, Pages: C386-C387, 2011 [doi]

Balomenou, Ioanna, Kaloudi-Chantzea, Antonia, Karakostas, Nikolaos, Yannakopoulou, Konstantina, Mavridis, Irene M and Pistolis, George, Controlling the stereospecificity of a volume-conserving adiabatic photoisomerization within a nanotubular self-assembled cage: a reversible light–heat torque converter The Journal of Physical Chemistry B, ACS Publications, Volume 115, Pages: 10665–10681, 2011 [doi]

Maffeo, D., Velkov, Z., Misiakos, K., Mergia, K., Paulidou, A., Zavali, M., Mavridis, I.M. and Yannakopoulou, K., Real-time monitoring of nanomolar binding to a cyclodextrin monolayer immobilized on a Si/SiO2/novolac surface using white light reflectance spectroscopy: The case of triclosan Journal of Colloid and Interface Science, Volume 358, Pages: 369-375, 2011 [doi]

Paulidou, Anastasia, Yannakopoulou, Konstantina and Mavridis, Irene M., Hydrolysis of glutaric anhydride to glutaric acid in the presence of beta-cyclodextrin. Crystallographic and NMR study JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, Volume 68, Pages: 297-303, 2010 [doi]

Paulidou, Anastasia, Maffeo, Davide, Yannakopoulou, Konstantina and Mavridis, Irene M., Similar modes of inclusion in complexes of beta-cyclodextrin with sulfonylurea hypoglycemic drugs CRYSTENGCOMM, Volume 12, Pages: 517-525, 2010 [doi]

Maffeo, D., Lampropoulou, M., Fardis, M., Lazarou, Y.G., Mavridis, I.M., Mavridou, D.A.I., Urso, E., Pratsinis, H., Kletsas, D. and Yannakopoulou, K., Novel polycarboxylated EDTA-type cyclodextrins as ligands for lanthanide binding: Study of their luminescence, relaxivity properties of Gd(iii) complexes, and PM3 theoretical calculations Organic and Biomolecular Chemistry, Volume 8, Pages: 1910-1921, 2010 [doi]

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