RESEARCH INTERESTS

cyclodextrin chemistry; supramolecular chemistry; NMR spectroscopic studies of molecules and host-guest systems; cyclodextrin-based bioactive and photoactive nanoconstructs

ABOUT/BIOGRAPHY

Dr. Yannakopoulou graduated from the University of Athens with a BS degree in Chemistry. She received her MSc degree in Chemistry from Clemson University, South Carolina, USA (with Prof. R.A. Abramovitch) and her PhD degree in Chemistry from the University of Florida, USA (1988, with Prof. A. R. Katritzky). She was then employed as a post-doctoral fellow at the University of Florida (1988-1989) and repatriated to join NCSR “Demokritos” under a post-doctoral contract (1989-1993). Currently she is Researcher A at the Institute of Nanoscience and Nanotechnology, NCSR “Demokritos”. Her research focuses mainly in supramolecular entities based on cyclodextrins and the employment of synthesis to design new derivatives with tailored properties for molecular transport towards  bio nano applications. Solution NMR spectroscopy is the main method to elucidate structures of derivatives and supramolecular complexes and assemblies. Specifically, points of interest include stability and equilibria of cyclodextrin-guest systems in solution; synthetic modifications of cyclodextrins to acquire specific properties (nucleotide and DNA carriers, cell penetrating agents, antimicrobial agents, nanoparticle formation); combinations of cyclodextrin derivatives with photoactive molecules and their nanoconstructs as multifunctional bio and photo active systems combining ROS production, drug transport and photoimaging for chemotoxic and photodynamic applications and/or tuned optical properties; and  cycldextrin derivatives for coordination with metal ions.

She has served as the coordinator of the EU FP7 project PEOPLE-ITN “Novel multifunctional cyclodextrin- based nanocarriers for drug encapsulation and delivery as a strategy to overcome current therapeutic drawbacks”, CYCLON (2009-2013), as partner in the FP7-ITN “Nanocarriers for the delivery of antimicrobial agents to fight resistance mechanisms” CycloN-Hit (2014-2018), partner in the ERA-NET EuroNanomed-II-JTC2015 "Nanoparticle mediated Photochemical internalization (PCI) of small anticancer drugs" PCInano project (2016-2021) and as participating scientist in previous EU and National projects. She has also served as an expert evaluator of several EU projects.  She has authored and co-authored 103 articles in international refereed journals and one book chapter and has participated in > 85 national and international conferences.

She is the Scientist in Charge of the high resolution NMR Lab for liquid samples NCSRD “Demokritos” since 1991 (250 and 500 MHz).

PUBLICATIONS

Panagiotakis, Stylianos, Mavroidi, Barbara, Athanasopoulos, Alexandros, Charalambidis, Georgios, Coutsolelos, Athanassios G., Pelecanou, Maria and Yannakopoulou, Konstantina, Amphiphilic Chlorin-β-cyclodextrin Conjugates in Photo-Triggered Drug Delivery: The Role of Aggregation ChemPlusChem, 2024 [doi]

Agnes, M., Kasimati, E.M., Inclán, M., Thanassoulas, A., Miliotis, G., Malanga, M., Benkovics, G., Nounesis, G., García-España, E., Bouziotis, P., Lazarou, Y.G., Miriagou, V., Mavridis, I.M. and Yannakopoulou, K., Metal-binding cyclodextrins: Synthesis and complexation with Zn2+ and Ga3+ cations towards antimicrobial applications Carbohydrate Polymers, Volume 321, Article Number: 121323, 2023 [doi]

Panagiotakis, Stylianos, Mavroidi, Barbara, Athanasopoulos, Alexandros, Gonçalves, Antonio Ricardo, Bugnicourt-Moreira, Loïc, Regagnon, Theo, Boukos, Nikos, Charalambidis, George, Coutsolelos, Athanasios G., Grigalavicius, Mantas, Theodossiou, Theodossis A., Berg, Kristian, Ladavière, Catherine, Pelecanou, Maria and Yannakopoulou, Konstantina, Small anticancer drug release by light: Photochemical internalization of porphyrin-β-cyclodextrin nanoparticles Carbohydrate Polymers, Volume 306, 2023 [doi]

Fakharuddin, Azhar, Armadorou, Konstantina-Kalliopi, Zorba, Leandros P., Tountas, Marinos, Seewald, Tobias, Soultati, Anastasia, Tsipas, Polychronis, Schütz, Emilia R., Tzoganakis, Nikolaos, Panagiotakis, Stylianos, Yannakopoulou, Konstantina, Dimoulas, Athanasios, Psycharis, Vassilis, Kymakis, Emmanuel, Yusoff, Abd Rashid bin Mohd, Aidinis, Konstantinos, Schmidt-Mende, Lukas, Vougioukalakis, Georgios C., Nazeeruddin, Mohammad Khaja and Vasilopoulou, Maria, A Triethyleneglycol C60 Mono-adduct Derivative for Efficient Electron Transport in Inverted Perovskite Solar Cells† Chinese Journal of Chemistry, Volume 41, Pages: 431 – 442, 2023 [doi]

Stergiou, A., Binou, P., Igoumenidis, P.E., Chiou, A., Yannakopoulou, K. and Karathanos, V., Host–guest inclusion complexes of hydroxytyrosol with cyclodextrins: Development of a potential functional ingredient for food application Journal of Food Science, Volume 87, Pages: 2678-2691, 2022 [doi]

Saridakis, E., Kasimati, E.-M., Yannakopoulou, K. and Mavridis, I.M., A guanidino-γ-cyclodextrin superdimer generates a twin receptor for phosphate dimers assembled by anti-electrostatic hydrogen bonds Chemical Communications, Volume 58, Pages: 5300-5303, 2022 [doi]

Panagiotakis, S., Saridakis, E., Malanga, M., Mavridis, I.M. and Yannakopoulou, K., A Self-locked β-Cyclodextrin-rhodamine B Spirolactam with Photoswitching Properties Chemistry - An Asian Journal, Volume 17, Article Number: e202101282, 2022 [doi]

Grigalavicius, M., Ezzatpanah, S., Papakyriakou, A., Raabe, T.T.H., Yannakopoulou, K. and Theodossiou, T.A., 5-ALA Is a Potent Lactate Dehydrogenase Inhibitor but Not a Substrate: Implications for Cell Glycolysis and New Avenues in 5-ALA-Mediated Anticancer Action Cancers, Volume 14, Article Number: 4003, 2022 [doi]

Panagiotakis, S., Mavroidi, B., Athanasopoulos, A., Charalambidis, G., Coutsolelos, A.G., Paravatou-Petsotas, M., Pelecanou, M., Mavridis, I.M. and Yannakopoulou, K., Unsymmetrical, monocarboxyalkyl meso-arylporphyrins in the photokilling of breast cancer cells using permethyl-β-cyclodextrin as sequestrant and cell uptake modulator Carbohydrate Polymers, Volume 275, Article Number: 118666, 2022 [doi]

Verykios, Apostolis, Soultati, Anastasia, Tourlouki, Konstantina, Katsogridakis, Charalampos, Alexandropoulos, Dimitris, Vidali, Veroniki P., Panagiotakis, Stylianos, Yannakopoulou, Konstantina, Dimotikali, Dimitra, Fakis, Mihalis, Palilis, Leonidas C. and Stathopoulos, Nikolaos, Pistolis, George, Skandamis, Panagiotis N., Argitis, Panagiotis and Vasilopoulou, Maria, Commercially available chromophores as low-cost efficient electron injection layers for organic light emitting diodes JOURNAL OF PHYSICS D-APPLIED PHYSICS, Volume 55, 2022 [doi]

Tountas, Marinos, Soultati, Anastasia, Armadorou, Konstantina-Kalliopi, Ladomenou, Kalliopi, Landrou, Georgios, Verykios, Apostolis, Skoulikidou, Maria-Christina, Panagiotakis, Stylianos, Fillipatos, Petros-Panagis, Yannakopoulou, Konstantina, Chroneos, Alexander, Palilis, Leonidas C., Yusoff, Abd Rashid Bin Mohd, Coutsolelos, Athanassios G., Argitis, Panagiotis and Vasilopoulou, Maria, Core-shell carbon-polymer quantum dot passivation for near infrared perovskite light emitting diodes JPhys Photonics, Volume 4, 2022 [doi]

Soultati, Anastasia, Nunzi, Francesca, Fakharuddin, Azhar, Verykios, Apostolis, Armadorou, Konstantina K., Tountas, Marinos, Panagiotakis, Stylianos, Polydorou, Ermioni, Charisiadis, Asterios, Nikolaou, Vasilis, Papadakis, Michael, Charalambidis, Georgios, Nikoloudakis, Emmanouil, Yannakopoulou, Konstantina, Bao, Xichang, Yang, Chunming, Dunbar, Alan D. F., Kymakis, Emmanuel, Palilis, Leonidas C., Mohd Yusoff, Abd Rashid Bin, Argitis, Panagiotis, Coutsolelos, Athanassios G., De Angelis, Filippo, Nazeeruddin, Mohammad Khaja and Vasilopoulou, Maria, Functionalized BODIPYs as Tailor-Made and Universal Interlayers for Efficient and Stable Organic and Perovskite Solar Cells Advanced Materials Interfaces, Volume 9, 2022 [doi]

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