RESEARCH INTERESTS

cyclodextrin chemistry; supramolecular chemistry; NMR spectroscopic studies of molecules and host-guest systems; cyclodextrin-based bioactive and photoactive nanoconstructs

ABOUT/BIOGRAPHY

Dr. Yannakopoulou graduated from the University of Athens with a BS degree in Chemistry. She received her MSc degree in Chemistry from Clemson University, South Carolina, USA (with Prof. R.A. Abramovitch) and her PhD degree in Chemistry from the University of Florida, USA (1988, with Prof. A. R. Katritzky). She was then employed as a post-doctoral fellow at the University of Florida (1988-1989) and repatriated to join NCSR “Demokritos” under a post-doctoral contract (1989-1993). Currently she is Researcher A at the Institute of Nanoscience and Nanotechnology, NCSR “Demokritos”. Her research focuses mainly in supramolecular entities based on cyclodextrins and the employment of synthesis to design new derivatives with tailored properties for molecular transport towards  bio nano applications. Solution NMR spectroscopy is the main method to elucidate structures of derivatives and supramolecular complexes and assemblies. Specifically, points of interest include stability and equilibria of cyclodextrin-guest systems in solution; synthetic modifications of cyclodextrins to acquire specific properties (nucleotide and DNA carriers, cell penetrating agents, antimicrobial agents, nanoparticle formation); combinations of cyclodextrin derivatives with photoactive molecules and their nanoconstructs as multifunctional bio and photo active systems combining ROS production, drug transport and photoimaging for chemotoxic and photodynamic applications and/or tuned optical properties; and  cycldextrin derivatives for coordination with metal ions.

She has served as the coordinator of the EU FP7 project PEOPLE-ITN “Novel multifunctional cyclodextrin- based nanocarriers for drug encapsulation and delivery as a strategy to overcome current therapeutic drawbacks”, CYCLON (2009-2013), as partner in the FP7-ITN “Nanocarriers for the delivery of antimicrobial agents to fight resistance mechanisms” CycloN-Hit (2014-2018), partner in the ERA-NET EuroNanomed-II-JTC2015 "Nanoparticle mediated Photochemical internalization (PCI) of small anticancer drugs" PCInano project (2016-2021) and as participating scientist in previous EU and National projects. She has also served as an expert evaluator of several EU projects.  She has authored and co-authored 103 articles in international refereed journals and one book chapter and has participated in > 85 national and international conferences.

She is the Scientist in Charge of the high resolution NMR Lab for liquid samples NCSRD “Demokritos” since 1991 (250 and 500 MHz).

PUBLICATIONS

Panagiotakis, Stylianos, Mavroidi, Barbara, Athanasopoulos, Alexandros, Charalambidis, Georgios, Coutsolelos, Athanassios G, Paravatou-Petsotas, Maria, Pelecanou, Maria, Mavridis, Irene M and Yannakopoulou, Konstantina, Unsymmetrical, monocarboxyalkyl meso-arylporphyrins in the photokilling of breast cancer cells using permethyl-$beta$-cyclodextrin as sequestrant and cell uptake modulator Carbohydrate Polymers, Elsevier, Volume 275, Pages: 118666, 2022 [doi]

Verykios, Apostolis, Soultati, Anastasia, Tourlouki, Konstantina, Katsogridakis, Charalampos, Alexandropoulos, Dimitris, Vidali, Veroniki P., Panagiotakis, Stylianos, Yannakopoulou, Konstantina, Dimotikali, Dimitra, Fakis, Mihalis, Palilis, Leonidas C. and Stathopoulos, Nikolaos, Pistolis, George, Skandamis, Panagiotis N., Argitis, Panagiotis and Vasilopoulou, Maria, Commercially available chromophores as low-cost efficient electron injection layers for organic light emitting diodes JOURNAL OF PHYSICS D-APPLIED PHYSICS, Volume 55, 2022 [doi]

Yannakopoulou, Konstantina, Panagiotakis, Stylianos, Saridakis, Emmanuel, Malanga, Milo and Mavridis, Irene M, A self-locked $beta$-cyclodextrin-rhodamine B spirolactam with photoswitching properties Chemistry–An Asian Journal, 2021 [doi]

Agnes, Marco, Arabi, Ameneh, Caricato, Marco, Nitti, Andrea and Dondi, Daniele, Yannakopoulou, Konstantina and Patrini, Maddalena and Pasini, Dario, Helical Nanofibers Formed by Palladium-Mediated Assembly of Organic Homochiral Macrocycles Containing Binaphthyl and Pyridyl Units CHEMPLUSCHEM, Volume 86, Pages: 270-274, 2021 [doi]

Soultati, A., Verykios, A., Panagiotakis, S., Armadorou, K.-K., Haider, M.I., Kaltzoglou, A., Drivas, C., Fakharuddin, A., Bao, X., Yang, C., Yusoff, A.R.B.M., Evangelou, E.K., Petsalakis, I., Kennou, S., Falaras, P., Yannakopoulou, K., Pistolis, G., Argitis, P. and Vasilopoulou, M., Suppressing the Photocatalytic Activity of Zinc Oxide Electron-Transport Layer in Nonfullerene Organic Solar Cells with a Pyrene-Bodipy Interlayer ACS Applied Materials and Interfaces, Volume 12, Pages: 21961-21973, 2020 [doi]

Thomsen, Hanna, Agnes, Marco, Uwangue, Owens, Persson, Linn'ea, Mattsson, Matilda, Graf, Fabrice E, Kasimati, Eleni-Marina, Yannakopoulou, Konstantina, Ericson, Marica B and Farewell, Anne, Increased antibiotic efficacy and noninvasive monitoring of Staphylococcus epidermidis biofilms using per-cysteamine-substituted $gamma$-cyclodextrin–A delivery effect validated by fluorescence microscopy International Journal of Pharmaceutics, Elsevier, Volume 587, Pages: 119646, 2020 [doi]

Mavridis, Irene M and Yannakopoulou, Konstantina, Porphyrinoid–Cyclodextrin assemblies in biomedical research: an update Journal of medicinal chemistry, American Chemical Society, Volume 63, Pages: 3391–3424, 2019 [doi]

Benkovics, Gabor, Balint, Mihaly, Fenyvesi, Eva, Varga, Erzsebet, Beni, Szabolcs, Yannakopoulou, Konstantina and Malanga, Milo, Homo- and hetero-difunctionalized beta-cyclodextrins: Short direct synthesis in gram scale and analysis of regiochemistry BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, Volume 15, Pages: 710-720, 2019 [doi]

Dimitriadi, Maria, Panagiotopoulou, Angeliki, Pelecanou, Maria and Yannakopoulou, Konstantina and Eliades, George, Stability and reactivity of gamma-MPTMS silane in some commercial primer and adhesive formulations DENTAL MATERIALS, Volume 34, Pages: 1089-1101, 2018 [doi]

Popielec, Agnieszka, Agnes, Marco, Yannakopoulou, Konstantina and Fenyvesi, Eva and Loftsson, Thorsteinn, Effect of beta- and gamma-cyclodextrins and their methylated derivatives on the degradation rate of benzylpenicillin JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, Volume 91, Pages: 199-209, 2018 [doi]

Popielec, Agnieszka, Agnes, Marco, Yannakopoulou, Konstantina and Fenyvesi, Eva and Loftsson, Thorsteinn, Self-assembled cyclodextrin-based nanoparticles for meropenem stabilization JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, Volume 45, Pages: 20-27, 2018 [doi]

Shankarayya Wadi, Vijay Kumar, Jena, Kishore K., Khawaja, Shahrukh Z., Yannakopoulou, Konstantina, Fardis, Michael, Mitrikas, George, Karagianni, Marina, Papavassiliou, Georgios and Alhassan, Saeed M., NMR and EPR Structural Analysis and Stability Study of Inverse Vulcanized Sulfur Copolymers ACS Omega, Volume 3, Pages: 3330-3339, 2018 [doi]

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