PoC/PoN silicon optical biosensors, solar cells, radiation detectors



  • B.S. in Electrical Engineering at the National Technical  University of Athens, Greece,  1978.  
  • M.S. in Electrical Engineering, Clemson University, Clemson, SC, 1984.
  •  Ph.D in Electrical Engineering on semiconductor device physics, University of Florida, Gainesville, FL, August 1987.


  • Visiting Assistant Professor in electrical engineering at the University of Florida from August 1987 to May 1989. 
  • Research Associate at the Microelectronics Inst. NCSR "Demokritos"  from June 1989-June 1995. Working on simulation, design fabrication and characterization of  silicon radiation detectors and optical biosensors.
  • Director of Research at INN, NCSR "Demokritos" since February 2000, and Senior Researcher from June 1995 to February 2000. His research interests include optical biosensors, monolithic silicon optocouplers for biosensing, and bipolar devices. The biosensors developed detect blood markers and harmful substances in food. Dr. Misiakos is the author or co-author of 119 publications in refereed international journals, 63 communications in international conferences, four book chapters and holds a US patent on interferometric optical biosensors integrated on silicon (US Patent No. 11,119,040). The EU patent is pending.  Along with his co-researchers Drs. E. Makarona, S. Kakabakos, P. Petrou and Mr. A. Salapatas they are actively pursuing to commercialize the single sided silicon interferometric chips as dip-and-read biosensors. He has supervised 4 Ph.Ds and has coordinated three European projects :  EU-BRITE III Project “BOEMIS” BRPR-CT97-0393 (1997-2000), EU-IST Project “BIOMIC” FP5-IST-2000-28214 (2001-2004)  and the  EU-IST project “NEMOSLAB” FP6-IST-027804 (2006-2009), all in biosensors.



Angelopoulou, M., Petrou, P.S., Raptis, I., Misiakos, K., Livaniou, E., Makarona, E. and Kakabakos, S., Rapid detection of mozzarella and feta cheese adulteration with cow milk through a silicon photonic immunosensor Analyst, Volume 146, Pages: 529-537, 2021 [doi]

Stavra, E., Petrou, P.S., Koukouvinos, G., Economou, A., Goustouridis, D., Misiakos, K., Raptis, I. and Kakabakos, S.E., Fast, sensitive and selective determination of herbicide glyphosate in water samples with a White Light Reflectance Spectroscopy immunosensor Talanta, Volume 214, Article Number: 120854, 2020 [doi]

Korompili, G., Misiakos, K. and Chronis, N., An optoelectronic chip with integrated epi-illumination source and collection optics for imaging applications Sensors and Actuators, A: Physical, Volume 312, Article Number: 112082, 2020 [doi]

Gajos, K., Budkowski, A., Petrou, P., Awsiuk, K., Misiakos, K., Raptis, I. and Kakabakos, S., Spatially selective biomolecules immobilization on silicon nitride waveguides through contact printing onto plasma treated photolithographic micropattern: Step-by-step analysis with TOF-SIMS chemical imaging Applied Surface Science, Volume 506, Article Number: 145002, 2020 [doi]

Tsounidi, D., Koukouvinos, G., Petrou, P., Misiakos, K., Zisis, G., Goustouridis, D., Raptis, I. and Kakabakos, S.E., Rapid and sensitive label-free determination of aflatoxin M1 levels in milk through a White Light Reflectance Spectroscopy immunosensor Sensors and Actuators, B: Chemical, Volume 282, Pages: 104-111, 2019 [doi]

Misiakos, K., Makarona, E., Hoekman, M., Fyrogenis, R., Tukkiniemi, K., Jobst, G., Petrou, P.S., Kakabakos, S.E., Salapatas, A., Goustouridis, D., Harjanne, M., Heimala, P. and Raptis, I., All-Silicon Spectrally Resolved Interferometric Circuit for Multiplexed Diagnostics: A Monolithic Lab-on-a-Chip Integrating All Active and Passive Components ACS Photonics, Volume 6, Pages: 1694-1705, 2019 [doi]

Petrou, P., Makarona, E., Kakabakos, S., Koukouvinos, G., Misiakos, K. and Raptis, I., Interferometry-based immunoassays Pages: 241-271, 2018 [doi]

Pagkali, V., Petrou, P.S., Makarona, E., Peters, J., Haasnoot, W., Jobst, G., Moser, I., Gajos, K., Budkowski, A., Economou, A., Misiakos, K., Raptis, I. and Kakabakos, S.E., Simultaneous determination of aflatoxin B1, fumonisin B1 and deoxynivalenol in beer samples with a label-free monolithically integrated optoelectronic biosensor Journal of Hazardous Materials, Volume 359, Pages: 445-453, 2018 [doi]

Koukouvinos, G., Goustouridis, D., Misiakos, K., Kakabakos, S., Raptis, I. and Petrou, P., Rapid C-reactive protein determination in whole blood with a White Light Reflectance Spectroscopy label-free immunosensor for Point-of-Care applications Sensors and Actuators, B: Chemical, Volume 260, Pages: 282-288, 2018 [doi]

Gajos, K., Budkowski, A., Petrou, P., Pagkali, V., Awsiuk, K., Rysz, J., Bernasik, A., Misiakos, K., Raptis, I. and Kakabakos, S., Protein adsorption/desorption and antibody binding stoichiometry on silicon interferometric biosensors examined with TOF-SIMS Applied Surface Science, Volume 444, Pages: 187-196, 2018 [doi]

Angelopoulou, M., Petrou, P.S., Makarona, E., Haasnoot, W., Moser, I., Jobst, G., Goustouridis, D., Lees, M., Kalatzi, K., Raptis, I., Misiakos, K. and Kakabakos, S.E., Ultrafast Multiplexed-Allergen Detection through Advanced Fluidic Design and Monolithic Interferometric Silicon Chips Analytical Chemistry, Volume 90, Pages: 9559-9567, 2018 [doi]

Anastasopoulou, M., Malainou, A., Salapatas, A., Chronis, N., Raptis, I. and Misiakos, K., Label-free detection of the IL-6 and IL-8 interleukines through monolithic silicon photonic chips and simultaneous dual polarization optics Sensors and Actuators, B: Chemical, Volume 256, Pages: 304-309, 2018 [doi]

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