3D Scaffolds for tissue engineering

Our work is focused on the development of hydroxyapatite nanoparticles using dendritic polymers as biomimetic templates. Following their successful preparation,1,2 hydroxyapatite nanoparticles were employed for the development of biopolymer/nanohydroxyapatite porous personalized 3D bio-implants of complex geometry.3 A number of studies were performed providing evidence that these scaffolds exhibit increased biocompatibility and bioactivity and are able to promote guided bone regeneration in rat calvarial critical-sized defects.4-6

Hydroxyapatite nanoparticles (nHAp), nHAp/Chitosan scaffold morphology and 3D scaffolds of complex geometry.

New bone formation over time in critical-size defects (CSDs) bilaterally trephined in the parietal bone of Sprague-Dawley rats (group A: control; group B: experimental group).

The work was partially supported by a national project (see BIOMINY project). 

Relevant Publications

1. D. Tsiourvas, A. Tsetsekou, M.-I. Kammenou, N. Boukos, Controlling the formation of hydroxyapatite nanorods with dendrimers, J. Am. Ceram. Soc., 94, 2023–2029 (2011).

2. D. Tsiourvas, A. Tsetsekou, M.-I. Kammenou, N. Boukos, Biomimetic synthesis of ribbon-like hydroxyapatite employing poly(L-arginine), Materials Science and Engineering C, 58, 1225–1231 (2016).

3. D. Tsiourvas, A. Sapalidis, T. Papadopoulos, Hydroxyapatite/chitosan-based porous three-dimensional scaffolds with complex geometries, Materials Today Communications 7, 59–66 (2016).

4. E. Chatzipetros, S. Damaskos, K. I. Tosios, P. Christopoulos, C. Donta, E.-M. Kalogirou, Z. Yfanti, D. Tsiourvas, A. Papavasiliou, K. Tsiklakis, The effect of nano-hydroxyapatite/chitosan scaffolds on rat calvarial defects for bone regeneration, International Journal of Implant Dentistry, 7, 40 (2021); doi:10.1186/s40729-021-00327-w.

5. E. Chatzipetros, Z. Yfanti, P. Christopoulos, C. Donta, S. Damaskos, E. Tsiambas, D. Tsiourvas, E.-M. Kalogirou, K. I. Tosios, K. Tsiklakis, Imaging of nano-hydroxyapatite/chitosan scaffolds using a cone beam computed tomography device on rat calvarial defects with histological verification, Clinical Oral Investigations, 24, 437–446 (2020); doi:10.1007/s00784-019-02939-4.

6. E. Chatzipetros, P. Christopoulos, C. Donta, K. I. Tosios, E. Tsiambas, D. Tsiourvas, E.-M. Kalogirou, K. Tsiklakis, Application of nano-hydroxyapatite/chitosan scaffolds on rat calvarial critical-sized defects: A pilot study, Med. Oral Patol. Oral Cir. Bucal. 23, e625–632 (2018); doi:10.4317/medoral.22455.

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