Structural & Supramolecular Chemistry Research Group – Journals


Positively charged cyclodextrins as effective molecular transporters of active phosphorylated forms of gemcitabine into cancer cells. V. Rodriguez-Ruiz, A. Maksimenko, G. Salzano, M. Lampropoulou, Y. G. Lazarou, V. Agostoni, R. Gref, K. Yannakopoulou Scientific Reports 2017, 7: 8353

Formation, characterization and pH dependence of rifampicin:heptakis(2,6-di-O-methyl)-β-cyclodextrin complexes. L. Angiolini, M. Agnes, B. Cohen, K. Yannakopoulou, A. Douhal Int. J. Pharm. 2017, 531, 668-675.  

Cyclodextrin-mesoporous silica particle composites for controlled antibiotic release. A proof of concept toward colon targeting. L. Stjern, S. Voittonen, R. Weldemichel, S. Thuresson, M. Agnes, G. Benkovics, É. Fenyvesi, M. Malanga, K. Yannakopoulou, A. Feiler, S. Valetti Int. J. Pharm. 2017, 531, 595-605.

Molecular recognition of N-acetyltryptophan enantiomers by β-cyclodextin. S. D. Chatziefthimiou, M. Inclán, P. Giastas, A. Papakyriakou, K. Yannakopoulou, I. M. Mavridis Beilst. J. Org. Chem. 2017, 13, 1572–1582.

Enhanced gefitinib cytotoxicity in the presence of cyclodextrins: in-vitro and biophysical studies towards potential therapeutic interventions for cancer. K. Ηatziagapiou, K. Bethanis, G. I. Lambrou, K. Yannakopoulou, M. Karpusas, M. Braoudaki, E. Christofo­rides, F. Tsorteki, V. Milionis, N. Kavantzas, F. Tzortzatou-Stathopoulou,V. Gemou-Engesaeth J. Biomed. Nanotechnol.  2017, 13, 1-12.

Designed positively charged cyclodextrin hosts with enhanced binding of penicillins as carriers for the delivery of antibiotics: the case of oxacillin. M. Agnes, A. Thanassoulas, P. Stavropoulos, G. Nounesis, G. Miliotis, V. Miriagou, E. Athanasiou, G. Benkovics, M. Malanga, K. Yannakopoulou, Int. J. Pharm. 2017, 531, 480-491.

Green extraction of polyphenols from whole pomegranate fruit using cyclodextrins. A. C. Diamanti, P. E. Igoumenidis, I. Mourtzinos, K. Yannakopoulou, V. T. Karathanos Food. Chem. 2017, 214, 61-66.

Ligand-induced conformational change of insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity.    A. Mpakali, E. Saridakis, K. Harlos, Y. Zhao, P.  Kokkala, D.  Georgiadis, P. Giastas, A., Papakyriakou, E. Stratikos, J. Med. Chem. 2017, 60, 2963-2972.

Crystal structures of ERAP2 complexed with inhibitors reveal pharmacophore requirements for optimizing inhibitor potency. A. Mpakali, P. Giastas, R. Deprez-Poulain, A. Papakyriakou, D. Koumantou, R.  Gealageas, S. Tsoukalidou, D. Vourloumis, I. M.  Mavridis, E. Stratikos, E.  Saridakis, ACS Med. Chem. Lett. 2017, 8, 333-337.

Protein crystal nucleation in pores. C. N. Nanev, E. Saridakis, N. E. Chayen, Scientific Reports 2017, 7: 35821.



Effect of cyclodextrins on the degradation rate of benzylpenicillin  A.Popielec, E. Fenyvesi, K. Yannakopoulou, T. Loftsson, Die PHARMAZIE, 2016, 71, 68–75.

Theoretical investigation of microcystin-LR, microcystin-RR and 3 nodularin-R  complexation with α-, β-, and γ-cyclodextrin as a starting 4 point for the targeted design of efficient cyanotoxin traps A. S. Archimandritis, Th. Papadimitriou, K. A. Kormas, Ch. S. Laspidou, K. Yannakopoulou, Y.G. Lazarou, Sustain. Chem. Pharm. 2016, 3, 25-32.

Influence of precipitating agents on thermodynamic parameters of protein crystallization solutions. P. Stavros, E. Saridakis, G. Nounesis, Biopolymers, 2016, 105, 642-652.

Reductively PEGylated carbon nanomaterials and their use to nucleate 3D protein crystals: A comparison of dimensionality H. S. Leese, L. Govada, E. Saridakis, S. Khurwshid, R. Menzel, T. Morishita, A. J. Clancy, E. R. White, N. E. Chayen, M. S. P. Shaffer, Chem. Sci. 2016, 7, 2916-2923.

Exploring carbon nanomaterial diversity for nucleation of protein crystals, L. Govada, H. S. Leese, E. Saridakis, S. Kassen, B. Chain, S. Khurwshid, R. Menzel, S. Hu, M. S. P. Shaffer, N. E. Chayen, Scientific Reports, 2016, 6: 20053.


Efficient ‘‘green” encapsulation of a highly hydrophilic anticancer drug in metal–organic framework nanoparticles V. Rodriguez-Ruiz, A. Maksimenko, R. Anand, S. Monti, V. Agostoni, P. Couvreur, M. Lampropoulou, K. Yannakopoulou, R. Gref J. Drug Target. 2015, 23, 759–767.

Anionic cyclodextrins as versatile hosts for pharmaceutical nanotechnology: Synthesis, drug delivery, enantioselectivity, contrast agents for MRI. I.M. Mavridis, K. Yannakopoulou Int. J. Pharm. 2015, 492, 275-290.

Synthesis of cyclodextrin derivatives with monosacharides and their binding with ampicillin and selected lectins. M. Lampropoulou, K. Misiakos, M. Paravatou, I. M. Mavridis, K. Yannakopoulou ARKIVOC, Part 3  2015, 232-243.

Photochemical Internalization of Tamoxifens Transported by a Trojan-Horse Nanoconjugate into Breast-Cancer Cell Lines. T. A. Theodossiou, A. R. Goncalves, K. Yannakopoulou, E. Skarpen, K. Berg  Angew. Chem. Int. Ed. 2015, 54 4885–4889.

Crystal structure of Insulin-Regulated Aminopeptidase with bound substrate analogue provides insight on antigenic epitope precursor recognition and processing. A. Mpakali, E. Saridakis, K. Harlos, Y. Zhao, A. Papakyriakou, P. Kokkala, D. Georgiadis, E. Stratikos J. Immunol. 2015, 195, 2842-2851.

Structural basis for antigenic peptide recognition and processing by ER aminopeptidase 2. A. Mpakali, P. Giastas, N. Mathioudakis, I.M. Mavridis, E. Saridakis, E. Stratikos J. Biol. Chem. 2015, 290, 26021-26032.

A linear epitope in the N-terminal domain of CCR5 and its interaction with antibody. B. Chain, J. Arnold, S. Akthar, M. Brandt, D. Davis, M. Noursadeghi, T. Lapp, C. Ji, S. Sankuratri, Y. Zhang, L. Govada, E. Saridakis, N.E. Chayen PLoS ONE  2015, 10, e0128381.


Highly efficient and unidirectional energy transfer within a tightly self-assembled host–guest multichromophoric array. N. Karakostas, I. M. Mavridis, K. Seintis, M. Fakis, E. N. Koini, I. D. Petsalakis, G. Pistolis Chem. Commun. 2014, 50, 1362-1365.

Staudinger ligation towards cyclodextrin dimers in aqueous/organic media. Synthesis, conformations and guest-encapsulation ability. D. Manouilidou, Y. G. Lazarou, I. M. Mavridis, K. Yannakopoulou Beilst. J. Org. Chem. 2014, 10, 774-783.

Photophysics and ex vivo biodistribution of β-cyclodextrin–meso-tetra(m-hydroxy­phenyl)porphyrin conjugate for biomedical applications. V. Kirejev, AR. Gonçalves, C. Aggelidou, I. Manet, J. Mårtensson, K. Yannakopoulou, M. B. Ericson Photochem. Photobiol. Sci. 2014, 13, 1185-1191.

A versatile δ-aminolevulinic acid (ΑLA)-cyclodextrin bimodal conjugate-prodrug for PDT applications with the help of intracellular chemistry. C. Aggelidou, T. A. Theodossiou, A. R. Gonçalves, M. Lampropoulou, K. Yannakopoulou Beilst. J. Org. Chem. 2014, 10, 2414–2420.

An extended active-site motif controls the reactivity of the thioredoxin fold. D.A.I. Mavridou, E. Saridakis, P. Kritsiligkou, E. C. Mozley, S. J. Ferguson, C. Redfield J. Biol. Chem. 2014, 289, 8681-8696.

Porous nucleating agents for protein crystallization S. Khurshid, E. Saridakis, L. Govada, N. E. Chayen Nature Protoc. 2014, 9, 1621-1633.


S-Nitroso-β-cyclodextrins as novel bimodal carriers: preparation, detailed characterization, nitric oxide release and molecular encapsulation. L. Piras, T. A. Theodossiou, M. D. Manouilidou, S. Sortino, K. Yannakopoulou Chem. Asian J. 2013, 8, 2768-2778.

A multifunctional bichromophoric nanoaggregate for fluorescence imaging and simultaneous photogeneration of RNOS and ROS. A. Fraix, A. R. Gonçalves, V. Cardile, A. C. E. Graziano, T. A. Theodossiou, K. Yannakopoulou, S. Sortino Chem. Asian J. 2013, 8, 2634-2641.

Protoporphyrin IX-β-cyclodextrin bimodal conjugate: nanosized drug transporter and potent phototoxin. C. Aggelidou, T. A. Theodossiou, K. Yannakopoulou Photochem. Photobiol. 2013, 89, 1011-1019.

Imprinted polymers assisting protein crystallization. E. Saridakis, N. E. Chayen Trends Biotech. 2013, 31, 515-520.

A rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses. E. Zervoudi, E. Saridakis, J.R. Birtley, S. Seregin, E. Reeves, P. Kokkala, Y.A. Aldhamen, A. Amalfitano, I.M. Mavridis, E. James, D. Georgiadis, E. Stratikos Proc. Natl. Acad. Sci. U.S.A. 2013 110, 19890-19895.

Structural characterization of inorganic biomaterials I. M. Mavridis in Biomedical Inorganic Polymers, Progress in Molecular and Subcellular Biology book series (PMSB, volume 54) W.E.G. Müller X. Wang and H.C. Schöder Eds, Springer 2013, pp 19-38.


Perspectives on high-throughput technologies applied to protein crystallization. E. Saridakis Protein Pept. Lett. 2012, 19, 778-783.

Crystal structure of human ER aminopeptidase 2 reveals atomic basis for distinct roles in antigen processing J. R. Birtley, E. Saridakis, E. Stratikos, I. M. Mavridis Biochemistry 2012, 51, 286–295.

Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. N. Pinotsis, S. D. Chatziefthimiou, F. Berkemeier, F. Beuron, I. M. Mavridis, P. V. Konarev, D. I. Svergun, E. Morris, M. Rief, M. Wilmanns PLoS Biol. 2012, 10(2):e1001261.

A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing I. Evnouchidou, J. Birtley, S. Seregin, A. Papakyriakou, E. Zervoudi, M. Samiotaki, G. Panayotou, P. Giastas, O. Petrakis, D. Georgiadis, A. Amalfitano, E. Saridakis, I. M. Mavridis, E. Stratikos J. Immunol. 2012, 189, 2383-2392.

Electronic transport between Au surface and STM tip via a multipodal cyclodextrin host – metallo-guest supramolecular system L. E. P. Kyllönen, V. Chinuswamy, D. Maffeo, E. T. Kefalas, J. M. Haider, Z. Pikramenou, I. M. Mavridis, K. Yannakopoulou, N. Glezos J Phys. Org. Chem. 2012, 25, 198–206.

Tamoxifen subcellular localization observation of cell-specific cytotoxicity enhancement by inhibition of mitochondrial ETC complexes I and III. T. A. Theodossiou, K. Yannakopoulou, C. Aggelidou and J. S. Hothersall Photochem. Photobiol. 2012, 88, 1016-1022.

Cationic cyclodextrins: cell penetrating agents and other diverse applications. K. Yannakopoulou J. Drug Del. Sci. Tech. 2012, 22 243-249.


Optimization of protein crystallization: the OptiCryst project A. Garcia-Caballero, J.A. Gavira, E. Pineda-Molina, N.E. Chayen, L. Govada, S. Khurshid, E. Saridakis, A. Boudjemline, M.J. Swann, P. Shaw Stewart, R.A. Briggs, S.A. Kolek, D. Oberthuer, K. Dierks, C. Betzel, M. Santana, J.R. Hobbs, P. Thaw, T.J. Savill,  J.R. Mesters, R. Hilgenfeld, N. Bonander and R.M. Bill. Cryst. Growth Des. 2011, 11, 2112–2121.

Supramolecular control of photochromism in a β-cyclodextrin/Schiff base system E. Hadjoudis, K. Yannakopoulou, S. D. Chatziefthimiou, A. Paulidou, I. M. Mavridis J Photochem. Photobiol. A: Chem. 2011, 217, 293–298.

Real time nanomolar detection of triclosan binding to an amphiphilic cyclodextrin immobilised on a surface using white light reflectometry D. Maffeo, Z. Velkov, K. Misiakos, K. Mergia, A. Paulidou, M. Zavali, I. M. Mavridis, K. Yannakopoulou J. Colloid Interf. Sci. 2011, 358, 369-375.

Cooperative Heterodimer Formation Between Per-Guadinylated and Carboxylated or Phoshporylated Cyclodextrins in DMSO and DMSO-Water Studied by NMR Spectroscopy and Microcalorimetry. K. Fotiadou, A. Thanassoulas, G. Nounesis, K. Yannakopoulou Supramol. Chem. 2011, 23, 493-500.

Symmetry requirements for the effective blocking of pore-forming toxins: comparative study with α-, β-, and γ-cyclodextrin derivatives. K. Yannakopoulou, L. Jicsinszky, C. Aggelidou, N. Mourtzis, T. M. Robinson, A. Yohannes, E. M. Nestorovich, S. Bezrukov, V. A. Karginov Antimicrob. Agents Chemother. (AAC) 2011, 55, 3594-3597.

Synthesis and characterisation of novel glycoclusters based on cell penetrating heptakis(6-aminoethylamino-6-deoxy)-β-cyclodextrin. M. Lampropoulou, K. Yannakopoulou J. Incl. Phen. Macrocycl. Chem. 2011, 70, 345-352.

Controlling the Stereospecificity of a Volume-Conserving Adiabatic Photoisomerization within a Nanotubular Self-Assembled Cage: A Reversible Light-Heat Torque Converter. I. Balomenou, A. Kaloudi-Chantzea, N. Karakostas, K. Yannakopoulou, I. M. Mavridis, G Pistolis, J. Phys. Chem. B. 2011, 115, 10665-10681.

Use of Dual Polarisation Interferometry as a diagnostic tool for protein crystallization. A. Boudjemline, E. Saridakis, M. J. Swann, L. Govada, I. M. Mavridis, N. E. Chayen, Anal. Chem. 2011, 83, 7881-7887.

Oxidation-state-dependent protein-protein interactions in disulfide cascades. D.A.I. Mavridou, E. Saridakis, P. Kritsiligkou, A.D. Goddard, J.M. Stevens, S.J. Ferguson and C. Redfield. J. Biol. Chem. 2011, 286, 24943-24956.

Synthesis of 5,6-spiroethers and evaluation of their affinities for the bacterial A-site. I. A. Katsoulis, G. Kythreoti, A. Papakyriakou, K. Koltsida, P. Anastasopoulou, C.I. Stathakis, I. Mavridis, T. Cottin, E. Saridakis, D. Vourloumis. ChemBioChem 2011, 12, 1188-1192.

A novel Genetic Algorithm-inspired concept for macromolecular crystal optimization. E. Saridakis Crystal Growth Des. 2011, 11, 2993-2998.

Protein crystallization facilitated by molecularly imprinted polymers. E. Saridakis, S. Khurshid, L. Govada, Q. Phan, D. Hawkins, G.V. Crichlow, E. Lolis, S.M. Reddy and N.E. Chayen Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 11081-11086.


Novel polycarboxylated EDTA-type cyclodextrins as ligands for lanthanide binding: study of their luminescence, relaxivity properties of Gd(III) complexes, and PM3 theoretical calculations. D. Maffeo, M. Lampropoulou, M. Fardis, Y. G. Lazarou, I. M. Mavridis, D.A.I. Mavridou, E. Urso, H. Pratsinis, D. Kletsas, K. Yannakopoulou Org. Biomol. Chem. 2010, 8, 1910-1921.

Polyphenol characterization and encapsulation in β-cyclodextrin of a flavonoid-rich Hypericum perforatum (St John’s wort) extract. N. Kalogeropoulos, K. Yannakopoulou, A. Gioxari, A. Chiou, D. P Makris LWT- Food Sci. Tech. 2010, 43, 882-889.

Hydrolysis of glutaric anhydride to glutaric acid in the presence of β-cyclodextrin. Crystallographic and NMR study. A. Paulidou, K. Yannakopoulou, I. M. Mavridis J Incl. Phenom. Macrocycl. Chem. 2010, 68, 297–303

Thermally-induced acid generation from 18-molybdodiphosphate and 18-tungstodiphosphate within poly(2-hydroxyethyl methacrylate) Films. A. Douvas, K. Yannakopoulou, P. Argitis Chem. Mater., 2010, 2, 2730-2740.

Coordination-driven self-assembly of a brilliantly fluorescent rhomboid cavitand composed of bodipy-dye subunits. A. Kaloudi-Chantzea, N. Karakostas, C.P. Raptopoulou, V. Psycharis, E. Saridakis, J. Griebel, R. Hermann and G. Pistolis J. Am. Chem. Soc. 2010, 132, 16327-16329.

Similar modes of inclusion in complexes of β-cyclodextrin with sulfonylurea hypoglycemic drugs. A. Paulidou, D. Maffeo, K. Yannakopoulou, I.M. Mavridis  Cryst. Eng. Commun. 2010, 12, 517–525.


Anils: Photochromism by H-transfer. E. Hadjoudis, S. D. Chatziefthimiou, I. M. Mavridis, Current Org. Chem. 2009, 13, 269-286

Binding of nucleotides and nucleosides to per(6-guanidino-6-deoxy)-cyclodextrins in solution. C. Aggelidou, I. M. Mavridis, K. Yannakopoulou Eur. J. Org. Chem. 2009, 2299-2305.

Insight into the protein and solvent contributions to the reduction potentials of [4Fe-4S]2+/+ clusters: Crystal structures of the Allochromatium vinosum ferredoxin variants C57A and V13G and the homologous Escherichia coli ferredoxin. E. Saridakis, P. Giastas, G. Efthymiou, V. Thoma, J-M. Moulis, P. Kyritsis, I. M. Mavridis J. Biolog. Inorg. Chem. 2009, 14, 783-799.

Towards a ‘universal’ nucleant for protein crystallization. E. Saridakis and N. E. Chayen Trends Biotech. 2009, 27, 99-106.

Carbon-nanotube based materials for protein crystallization. P. Asanithi, E. Saridakis, L. Govada, I. Jurewicz, E.W. Brunner, R. Ponnusamy, J.A.S. Cleaver,  A.B. Dalton, N.E. Chayen, R.P. Sear ACS Appl. Mat. Interf. 2009, 1, 1203-1210.


Thermal stability of Hibiscus sabdariffa L. anthocyanins in the presence of β-cyclodextrin. I. Mourtzinos, D. P. Makris, K. Yannakopoulou, N. Kalogeropoulos, I. Michali, V. T. Karathanos, J. Agric. Food Chem. 2008, 56, 10303–10310

Synthesis, characterisation, and remarkable biological properties of cyclodextrins bearing guanidino-alkylamino and aminoalkylamino groups on their primary side. N. Mourtzis, M. Paravatou, I. M. Mavridis, M. L. Roberts, K. Yannakopoulou  Chem. Eur. J. 2008, 14, 4188-4200.

Crystal structure of the inclusion complex of the antibacterial agent triclosan in β-cyclodextrin and NMR study of its molecular encapsulation in positively and negatively charged cyclodextrins. A. Paulidou, D. Maffeo, K. Yannakopoulou, I M. Mavridis Carbohydr. Res. 2008, 343, 2634-2640.

Molecular Nanodevices based on Functionalized Cyclodextrins. D. Velessiotis, D. Maffeo, E. Makarona, C. Viswanathan, K. Yannakopoulou, I. Mavridis, Z. Pikramenou, and N. Glezos Phys. Stat. Solid. 2008, 205, 2532-2535.

Protein crystallization: from purified protein to diffraction-quality crystal. N. E. Chayen, E. Saridakis Nature Meth. 2008, 5, 147-153.


Study of the solubility, antioxidant activity and structure of inclusion complex of vanillin with β-cyclodextrin. V. T. Karathanos, I. Mourtzinos, K. Yannakopoulou, N. K. Andrikopoulos Food Chem., 2007, 101, 652.

Synthesis and characterization of per(6-guanidino-6-deoxy)cyclodextrins and studies of their effect on DNA. N. Mourtzis, K. Eliadou, C. Aggelidou, V. Sophianopoulou, I. M. Mavridis, K. Yannakopoulou Org. Biomol. Chem. 2007, 5, 125-131.

Crystal and molecular structure of octakis(6-bromo-6-deoxy)-γ-cyclodextrin. A novel stacking of a distorted macrocycle. A.Paulidou, P. Giastas, N. Mourtzis, K. Yannakopoulou, I. M. Mavridis Carbohydr. Res. 2007, 342, 1519-1524.

β-Cyclodextrin trimers enclosing an unusual organization of guest: The inclusion complex β-Cyclodextrin/4-pyridinealdazine. S. D. Chatziefthimiou, K. Yannakopoulou, I. M. Mavridis Cryst. Eng. Comm. 2007 9, 976-979.

Encapsulation of olive leaf extract in β-Cyclodextrin. I. Mourtzinos, F. Salta, K. Yannakopoulou, A. Chiou, V. T. Karathanos J. Agr. Food Chem. 2007, 55, 8088-8094.


Positive effect of natural and negatively charged cyclodextrins on the stabilization of penicillins towards β-lactamase degradation due to inclusion and external guest-host association. An NMR and MS Study. D. Maffeo, L. Leondiadis, I. M. Mavridis, K. Yannakopoulou Org. Biomol. Chem. 2006, 4, 1297 – 1304.

Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk. P. Zou, N. Pinotsis, S. Lange, Y-H. Song, A. Popov, I. Mavridis, O. M. Mayans, M. Gautel, M. Wilmanns Nature 2006, 439, 225-228.

Cyclodextrins and their complexes. Chemistry, analytical methods & applications. K. Yannakopoulou, and I. M. Mavridis “Rotaxane and Catenane Structures Involving Cyclodextrins” in the Handbook H. Dodziuk, Ed. 2006, p. 356-369, ISBN 3-527-31280-3 Wiley-VCH, Weinheim.

The structure of the 2[4Fe-4S] ferredoxin from Pseudomonas aeruginosa at 1.32 Å resolution. Comparison with other high resolution structures of ferredoxins and contributing structural features to reduction potential values. P. Giastas, N. Pinotsis, G. Efthymiou, M. Wilmanns, P. Kyritsis, J- M. Moulis, I. M. Mavridis J. Biolog. Inorg. Chem. 2006, 11, 445-458.

Stable cis-keto forms of salicylaldehyde schiff bases:structural and theoretical aspects. S. D. Chatziefthimiou, Y. G. Lazarou, E. Hadjoudis, T. Dziembowska and I. M. Mavridis J. Phys Chem. B 2006, 110, 23701-23709.

Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their Receptor desmodynamic processes. S. De Luca, M. Saviano, L. Lassiani, Yannakopoulou K., P. Stefanidou, L. Aloj, G. Morelli, A. Varnavas J. Med. Chem. 2006, 49, 2456-2462.

Experiment and theory for heterogeneous nucleation of protein crystals in a porous medium. R. Sears, E. Saridakis and N. E. Chayen Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 597-601.

A model for enhanced nucleation of protein crystals on a fractal porous substrate. S. Stolyarova, E. Saridakis, N.E. Chayen & Y. Nemirovsky Biophys. J. 2006, 91, 3857-3863.

Far-red luminescent ruthenium pyridylimine complexes; building blocks for multinuclear arrays. A.C. G. Hotze, Faiz JA, N. Mourtzis, G. I. Pascu, P. R. A Webber, G. J. Clarkson, K. Yannakopoulou, Z. Pikramenou, M. J. Hannon Dalton Trans 2006 (24): 3025-3034.

Partially fluorinated, POSS-functionalized (meth)acrylate resists for 193nm-bilayer lithography. M. Douvas, F. Van Roey, M. Goethals, K. Papadokostaki, K. Yannakopoulou, D. Niakoula, E. Gogolides, P. Argitis Chem. Mater. 2006, 18, 4040-4048.


A Novel Control of Differential Inclusion Complexation in the Solid State by Seed Crystals. K. Yoshizawa, S. Toyota, F. Toda, S. Chatziefthimiou, P. Giastas, I. M. Mavridis, M. Kato Angew. Chem. Int. Ed. 2005, 44, 5097-5100.


Influence of host’s substitution on the orientation of the guest: pseudo-rotaxanes of charged cyclo­dextrins with methyl orange in solution. N. Mourtzis, K. Eliadou, K. Yannakopoulou Supramolecular Chem. 2004, 16, 587–593.

Threading of long end-functionalised organic molecules into cyclodextrins: Structural analysis in aqueous solution by NMR spectroscopy and in the solid state by X-ray crystallography. K. Yannakopoulou and I. M. Mavridis Current Org. Chem. 2004, 8, 25-34.

Efficient resolution of 2,2’-Dihydroxy-1,1’-binaphthyl by Inclusion complexation with chiral N-(3-Chloro-2-hydroxypropyl)-N,N,N-trimethylammonium chloride F. Toda, K. Yoshizawa, S. Hyoda, S. Toyota,  S. Chatziefthimiou, I. M. Mavridis Org. Biomol. Chem. 2004, 2, 449-451.

Structural characterization of per-6-bromo-2,3-di-O-acetyl-β-cyclodextrin, studied in solution by NMR spectroscopy and in the solid state as a methanol complex by X-ray crystallography. Unusual glucopyranose conformations in the crystal. P. Giastas, K. Eliadou, Z. F. Plyta, K. Yannakopoulou, and I. M. Mavridis Carbohydr. Res. 2004, 339, 1189-1194.

Photochromism and Thermochromism of solid trans- N,N΄- bis-(salicylidene)-1,2-cyclohexanediamines and trans-N,N΄-bis-(2-hydroxynaphthylidene))-1,2-cyclohexane­diamine. E. Hadjoudis, A. Rontoyianni, K. Ambroziak, T. Dziembowska, I. M. Mavridis J. Photochem. Photobiol. A: Chem. 2004, 162, 521-530.

Photochromism and Thermochromism of Schiff Bases in the Solid State: Structural Aspects. Ε. Hadjoudis, I. M. Mavridis Chem. Soc. Rev. 2004, 33, 579- 588.


Rotaxanation of Congo Red into γ-Cyclodextrin. Solution Structures and Thermodynamic Parameters of 1:1 and 2:2 Adducts, as Obtained from NMR Spectroscopy and Microcalorimetry. N. Mourtzis, G. Cordoyiannis, G. Nounesis, K. Yannakopoulou Supramol. Chem. 2003, 15, 639-649.

Photoreactions of 2- and 4-pyridones in their inclusion crystal with a host compound. M. Yagi, S. Hirano, S. Yoyota, F. Toda, P. Giastas and I. M. Marvidis J. Ηeterocyclic Chem. 2003, 59, 735-744.

Molecular structures of the inclusion complexes β-cyclodextrin/1,2-bis(4-aminophenyl) ethane and β-cyclodextrin/4,4΄-diaminobiphenyl. Packing of dimeric β-cyclodextrin inclusion complexes. P. Giastas, K. Yannakopoulou and I. M. Mavridis Acta Crystallogr. 2003, B59, 287-299.

The binding of beta and gamma-cyclodextrins to glycogen phosphorylase b: kinetic and crystallographic studies. N. Pinotsis, D. D. Leonidas, E. D. Chrysina, N. G. Oikonomakos, I. M. Mavridis Protein Sci. 2003, 12, 1914-1924. Cover of the issue.

Synthesis of 6-mono-6-deoxy-β-cyclodextrins substituted with isomeric aminobenzoic acids. structural characterization, conformational preferences and self-inclusion, as studied by nmr spectroscopy in aqueous solution, and by x-ray crystallography in the solid state. K. Eliadou, P. Giastas, K. Yannakopoulou, I. M. Mavridis J. Org. Chem. 2003, 68, 8550-8557.

Tautomerism by hydrogen transfer: the case of photochromic and thermochromic Schiff-bases. E. Hadjoudis and I. M. Mavridis Trends in Physical Chemistry 2003, 9, 141-149.


Release of the prays oleae pheromone, as a consequence of supramolecular structure: study of the β-cyclodextrin/(z)-7-tetradecenal complex by X-ray crystallography and by NMR spectroscopy in the solid state and in solution. K. Yannakopoulou, J. A. Ripmeester, I. M. Mavridis J. Chem. Soc. Perkin Trans. 2 2002, 1639-1644.

The self-association of the drug acemethacin and its interactions and stabilization with β-cyclodextrin in aqueous solution as inferred from NMR spectroscopy and HPLC studies. D. Zouvelekis, K. Yannakopoulou, I. M. Mavridis E. Antoniadou-Vyza Carbohydr. Res. 2002, 337, 1387-1395.

Dielectric relaxation of the β-cyclodextrin complexes with tridecanoic acid and 1,13-tridecanedioic acid. J. C. Papaioannou, T. C. Ghikas, I. M. Mavridis J. Inclus. Phenom. 2002, 43, 107-113.

2,4-Diamino-5-(1-naphthyl)-3,5-diaza-1-azoniaspiro [5.5]undeca-1,3-diene chloride. N. C. Papandreou, S. Makedonopoulou, E. Antoniadou-Vyza, I. M. Mavridis, S. J. Hamodrakas Acta Crystallogr. 2002, C58, 730-732.

Pseudorotaxanes of β-cyclodextrin with diamino end-functionalized oligo-phenyl and -benzyl compounds in solution and in the solid state. P. Giastas, N. Mourtzis, K. Yannakopoulou and I. M. Mavridis J. Incl. Phenom. Macrocycl. Chem. 2002, 44, 247-250.

NMR Spectral assignment of per-substituted key-intermediates of βCD and Implications in the structures of the derivatives. K. Eliadou, K. Yannakopoulou J. Incl. Phenom. Macrocyclic Chem., 2002, 44, 247.



Non-covalent interactions in the crystallization of the enantiomers of 1,7-dioxaspiro[5.5]undecane (olive fly sex pheromone) by enantiospecific cyclodextrin hosts, hexakis(2,3,6-tri-o-methyl)-α-cyclodextrin and heptakis(2,3,6-tri-o-methyl)-β-cyclodextrin. S. Makedonopoulou, K. Yannakopoulou, D. Mentzafos, V. Lamzin, A. Popov, I. M. Mavridis Acta Crystallogr. 2001, B57, 399-409.

Inclusion Compounds of Plant Growth Regulators in Cyclodextrins. Part II. Structure of the Complex of β-Cyclodextrin with β-Naphthyloxyacetic acid in solid state and in aqueous solution. A.Kokkinou, K. Yannakopoulou, I. M. Mavridis, D. Mentzafos Carbohydr. Res. 2001, 332, 85-94.

Partial thermal dethreading of [3]pseudorotaxanes of α-cyclodextrin with linear aliphatic α,ω-aminoacids in aqueous solution. A.Tsortos, K. Yannakopoulou, K. Eliadou, I.M. Mavridis and G. Nounesis J. Phys. Chem. 2001, B105, 2664-2667.

The dimeric complex of beta cyclodextrin with 1,14-tetradecanedioic acid. Comparison with related complexes. S. Makedonopoulou, I. M. Mavridis Carbohydr. Res. 2001, 335, 213-220.

2000 – 1996

Crystal structure of the inclusion complex of β-cyclodextrin with the aliphatic monoacids tridecanoic acid and (z)-tetradecenoic acid. Formation of [3]pseudorotaxanes. S. Makedonopoulou, J. Papaioannou, I. Argyroglou, I. M. Mavridis J. Incl. Phenom. 2000, 36,191-215. (Cover of the issue)

Structure of the inclusion complex of β-cyclodextrin with 1,12-dodecanodioic acid using synchrotron radiation data. A Detailed dimeric β-cyclodextrin structure. S. Makedonopoulou, I. M. Mavridis Acta Crystallogr. 2000, B56, 322-331.nfluence of the Guest on the Packing of Dimeric β-Cyclodextrin Complexes. I.M. Mavridis, in Current Challenges on Large Supramolecular Assemblies, Ed. G.Tsoucaris, NATO ARW, Kluwer Acad. Publ. 1999, 403, pp 393.

Structure of permethylated α-cyclodextrin (R)-()-1,7-dioxaspiro[5.5]undecane 1:1 complex. D. Mentzafos, I. M. Mavridis and K. Yannakopoulou J. Incl. Phenom. 1999, 33, 321-330.

Dimeric complex of α-cyclodextrin with 1,12-diaminododecane. Comparison with other α-cyclodextrin dimeric complexes. Α.Rontoyianni, I. M. Mavridis, Supramol. Chem. 1999, 10, 213-218.

NMR detection of simultaneous formation of [2]- and [3]pseudorotaxanes in aqueous solution between α-cyclodextrin and linear aliphatic α,ω-aminoacids, an α,ω-diamine and an α,ω-diacid of similar length, and comparison with the solid state structures. Κ. Eliadou, K. Yannakopoulou, A. Rontoyianni, I. M. Mavridis J. Org. Chem. 1999, 64, 6217-6226.

The dimeric complex of β-cyclodextrin with 1,13-tridecanedioic acid. S. Makedonopoulou, A. Tulinsky, I. M. Mavridis Supramol. Chem. 1999, 11, 73-81.

Dielectric relaxation of β-cyclodextrin complex with 4-t-butyl-benzyl alcohol. J. Papaioannou, N. Papadimitropoulos, I. M. Mavridis Mol. Phys. 1999, 97, 611-627.

Spectroscopic and structural studies of the thermochromism of solid di-anil of 2-hydroxy-5-methyl-isophthalaldehyde. E. Hadjoudis, I. M. Mavridis, T. Dziembowska, Z. Rozwadowski and R. Anulewicz Molecular Engineering 1999, 8, 97

Clay polyvinyl pyridine nanocomposites. K. G. Fournaris, M.A. Karakassides, D. Petridis, K. Yannakopoulou Chem. Mat. 1999, 11, 2372-2381

The crystal structure of heptakis(2,3,6-tri-O-methyl)-ß-cyclodextrin with methylcyclohexane. Α. Rontoyianni and I. M. Mavridis, R. Israel, G. Beurskens J. Incl.. Phenom. 1998, 32, 415-428.

Organization of long aliphatic monocarboxylic acids in β-cyclodextrin channels. Crystal structures of the inclusion complexes of tridecanoic acid and (Z)-tetradecenoic acid in β-cyclodextrin. S. Makedonopoulou, I. M. Mavridis, K. Yannakopoulou, J. Papaioannou “” J. Chem. Soc. Chem. Commun. 1998, 2133-2134.

Structural Aspects of Permethylated Cyclodextrins and Comparison to their Parent Oligosaccharides, as Derived from Unequivocally Assigned 1H and 13C NMR Spectra in Aqueous Solutions. A.Botsi, K. Yannakopoulou, B. Perly and E. Hadjoudis Magn. Reson. Chem. 1996, 34, 419-423.

AM1 calculations on inclusion complexes of cyclomaltoheptaose (β-cyclodextrin) with 1,7-dioxaspiro[5.5]undecane and nonanal, and comparison with experimental results. A. Botsi, K. Yannakopoulou,  E. Hadjoudis, and J. Waite, Carbohydr. Res. 1996, 283, 1-16.

β-Cyclodextrin (Z)-9-dodecen-1-ol 2:1 complex. D. Mentzafos and I. M. Mavridis, Acta Crystallogr. 1996, C52, 1220-1223.

β-Cyclodextrin nonanoic acid 1:1 complex. A. Rontoyanni, I. M. Mavridis Acta Crystallogr. 1996, C52, 2277-2281.

Chiral Recognition of (R)-()-1,7-Dioxaspiro[5.5]undecane by Hexakis(2,3,6-tri-O-methyl)-α-Cyclodextrin. K. Yannakopoulou, D. Mentzafos, I. M. Mavridis and K. Dandika Angew. Chem. Int. Ed. Engl. 1996, 35, 2480-2482.

Molecular graphics approaches in structure prediction and determination. E. Eliopoulos and I. M. Mavridis in Crystallography of Supramolecular Compounds, G.Tsoucaris, J. L. Atwood and J. Lipkowski, Eds., NATO ASI, Kluwer Acad. Publ. 1996, 480, 491-498.

An interactive-kinetic approach to the study of supramolecular structures. E. Eliopoulos and I. M. Mavridis in Crystallography of Supramolecular Compounds, G.Tsoucaris, J. L. Atwood and J. Lipkowski, Eds., NATO ASI, Kluwer Acad. Publ. 1996, 480, 499-511.

1995 – 1991

Reactions of phenyltriazolinedione with alkenes. Stereochemistry of the methanol adducts to aziridinium imine intermediates. I.Smonou, S. Khan, C. S. Foote, Y. Elemes, I. M. Mavridis, A. Pantidou, M. Orfanopoulos J. Am. Chem. Soc. 1995, 117, 7081-7087.

The mesomorphic behaviour of cyanopropylalkyldimethylammonium bromides. M. Arkas, K. Yannakopoulou, C. M. Paleos, P. Weber and A. Skoulios Liq. Cryst. 1995, 18, 563-569.

Positive or adverse effects of methylation on the inclusion behaviour of cyclodextrins. a comparative NMR study using pheromone constituents of the olive fruit fly. A. Botsi, K. Yannakopoulou, B. Perly and E. Hadjoudis J. Org. Chem. 1995, 60, 4017-4023.

Characterization of a positive-tone wet silylation process with the AZ 5214TM photoresist. E. Gogolides, K. Yannakopoulou, A. Traverse, A. G. Nassiopoulos, E. Tsoi, M. Hatzakis, Microelectronic Engineering, 1994, 25, 75-90.

Lithographic Evaluation of a New Wet Silylation Process Using Safe Solvents and the Commercial Photoresist AZ 52314 TM. E. Gogolides, K. H. Baik, K. Yannakopoulou, L. Van den hove, M. Hatzakis, Microelectronic Engineering, 1994, 23, 267-270.

Solid state photochromism and thermochromism of N-(5-bromo-salicylidene)-2-phenyl­ethylamine. A.Rontoyianni. E. Hadjoudis and I. M. Mavridis Mol. Cryst. Liq. Cryst. 1994, 242, 221-226.

Photoactivity within cyclodextrin cavities: inclusion complexes of anils with cyclodextrins. G. Pistolis, E. Hadjoudis and I. M. Mavridis, Mol. Cryst. Liq.Cryst. 1994, 242, 215-219.

Crystal structure of the heptakis (2,3,6-tri-o-methyl)-β-cyclodextrin complex with ethyldodecanoate ester. I. M. Mavridis, D. Mentzafos and H. Schenk, Carbohydr. Res. 1994, 253, 39-50.

The crystal structure of the inclusion complex of cyclomaltoheptaose with 4-tert-butyl­benzoic acid. A. Rontoyanni, I. M. Mavridis, E. Hadjoudis, A. J. M. Duisenberg, Carbohydr. Res. 1994, 252, 19-32.

The crystal structure of the inclusion complex of cyclomaltoheptaose (β -cyclodextrin ) with 3,5-dimethylbenzoic acid. A. Rontoyanni, I. M. Mavridis, J. Incl. Phenom. 1994, 18, 211-227.

Inclusion complexes of cyclomaltoheptaose (β-cyclodextrin) and its methylated derivatives with the main components of the pheromone of the olive fruit fly.  A. Botsi, K. Yannakopoulou, E. Hadjoudis, Carbohydr. Res. 1993, 241, 37-46.

NMR differentiation of enantiomeric (+)- and (-)-α-pinene via complexation with cyclo­dextrins in water. A. Botsi, K. Yannakopoulou, E. Hadjoudis and B. Perly J. Chem. Soc. Chem. Commun. 1993, 1085-1086.

The crystal structure of the inclusion complex of cyclomaltoheptaose (β-cyclodextrin) with 4-tert-Butyltoluene. I. M. Mavridis and   E. Hadjoudis, Carbohydr. Res. 1992, 229, 1-15.

The crystal structure of the inclusion complex of cyclomaltoheptaose (β-cyclodextrin) with 3,3-dimethylbutylamine. I. M. Mavridis, E. Hadjoudis, G. Tsoucaris, Carbohydr. Res. 1991, 220, 11-21.

Structural-directing effects in the photochromism of anils. E. Hadjoudis, I. Argyroglou, E. Lambi, I. Moustakali-Mavridis Molecular Engineering 1991, 1, 67-74.

The crystal structure of the 4-tert-butylbenzyl alcohol β-cyclodextrin complex. Common features in the geometry of the β-cyclodextrin dimeric complexes. D. Mentzafos, I. M. Mavridis, G. Le Bas, G.Tsoucaris Acta Crystallogr. 1991, B47, 746-757.